Role of Lipids in Modifying Oral Drug Delivery口服药改进中的类脂作用 pdf 免费 地址 txt lrf 下载 kindle umd

The principles and formulation of lipid-based drug delivery systems

With its promise for improving drug absorption, the emerging field of lipid-based drug delivery systems has attracted c***iderable attention from academia to industry. Filling the need for a standard text on the subject, this book assembles a group of experienced investigators and educators from the front line of pharmaceutical sciences to provide a comprehensive resource on the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery.

Presenting a solid grounding in the fundamental principles of lipid absorption in the intestines and vascular body systems, the text gives readers in-depth insight into the formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs.

Chapters cover:

·In***ction of drug transporters with excipients

·Formulation issues around lipid-based oral and paren***l delivery systems

·Biological implicati*** of lipid-based paren***l drug delivery systems

·Principles in the development of intravenous lipid emulsi***

·Protein adsorption patterns on paren***l lipid formulati***-a key factor·determining the in vivo fate

·Nanoparticle targeting for drug delivery across the blood-brain barrier

·Lipid-coated perfluorocarbon nanostructures as paren***l the***utic agents

Preface.

Contributors.

Chapter 1. In***ction of Drug Transporters with Excipients (K. Sandy Pang, Lichuan Liu, and Huadong Sun).

Chapter 2. Formulation Issues around Lipid-Based Oral and Paren***l Delivery Systems (Seong Hoon Jeong, Jae Hyung Park and Kinam Park).

Chapter 3. Lipid-Based Paren***l Drug Delivery Systems: Biological Implicati*** (Vladimir P. Torchilin).

Chapter 4. Principles in the Development of Intravenous Lipid Emulsi*** (Joanna Rossi and Jean-Christophe Leroux).

Chapter 5. Protein adsorption patterns on paren***l lipid formulati***-key factor determining the in vivo fate (Rainer H. Muller and Torsten M. Goppert).

Chapter 6. Nanoparticle targeting for drug delivery across the blood brain barrier (James Egbert, Werner Geldenhuys, Fancy Thomas, Paul R. Lockman, Russell J. Mumper and David D. Allen).

Chapter 7. Lipid-Coated Perfluorocarbon Nanostructures as Paren***l The***utic Agents (Evan C. Unger, Terry O. Matsunaga and Reena Zutshi).

Index.

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