纳米药物-多功能聚合物药物递送系统研究(英文版) pdf 免费 地址 txt lrf 下载 kindle umd

本书为全英文学术专著，主要介绍***响应聚合物和聚合物杂化纳米药物载体的设计、制备、表征和应用。全书包括四章， 章主要介绍纳米药物传递体如何实现跨越生物学屏障，改善药物分布，实现治疗的靶向；第二章主要介绍中空介孔硅材料作为载体的三重***响应药物释放系统；第三章主要介绍以中空介孔硅为载体的光热－化学联合治疗材料；第四章描述了以两亲聚合物作为载体的叶酸靶向光热－化学联合治疗聚合物材料。

Chapter 1 INTRODUCTION

1.1 Nanoparticles in Drug Delivery

1.1.1 Role of nanoparticles in drug delivery

1.1.2 Composition of drug delivery nanocarriers

1.1.3 FDA-approved the***utic nanoagents

1.2 Design Rules for Targeted Drug Delivery Nanoplatform

1.2.1 Stimuli-resp***ive drug release

1.2.2 Biocompatibility and biodegradability

1.2.3 Stability, size and targeting

1.3 P***othermal Therapy

1.3.1 NIR induced p***othermal therapy

1.3.2 NIR absorbing materials for p***othermal therapy

1.3.3 Polymer for the delivery of NIR-absorbing dye

1.3.4 Combined p***othermal-chemotherapy

Chapter 2 POLYMER-COATED HOLLOW MESOPO-ROUS SILICA NANOPARTICLES FOR TRIPLE-RESPONSIVE DRUG DELIVERY

2.1 Introduction

2.2 Materials and Methods

2.2.1 Preparation of o-nitrobenzyl linkage

2.2.2 Preparation of PDEAEMA coated HMSNs

2.2.3 Preparation of DOX-loaded nanoparticles

2.2.4 Drug release behavior

2.2.5 Cellular uptake study

2.2.6 Cytotoxicity study

2.3 Results and Discussiona

2.3.1 Preparation of HMSNs-PDEAEMA

2.3.2 Loading and triggered release of DOX

2.3.3 Cellular uptake and intracellular release

2.3.4 In vitro antimmor study

2.4 Conclusion

Chapter 3 POLYMERIC PRODRUG GRAFTED HOLLOW MESOPOROUS SILICA NANOPAR-TICLES ENCAPSULATING NIR-ABSOR BING

DYE FOR POTENT COMBINED PHOTOTHERMAL-CHEMOTHERAPY

3.1 Introduction

3.2 Materials and Methods

3.2.1 Synthesis of HMSNs-RAFT

3.2.2 HMSNs-DOX prodrug

3.2.3 Preparation of HMSNs-DOXIP

3.2.4 Drug release, dye loading and p***othermal effect

3.2.5 Cellular uptake study

3.2.6 In vitro cytotoxicity study

3.3 Results and Discussion

3.3.1 Synthesis and characterization of HMSNs-DOX

3.3.2 Drug release, dye loading and p***othermal effects

3.3.3 Cellular uptake and intracellular release

3.3.4 In vitro antitumor study

3.4 Conclusion

Chapter 4 ACID-SENSITIVE POLYMERIC DOXORUBICIN PRODRU***ICELLES ENCAPSULATING NEAR-INFRARED DYE FOR

TARGETED COMBINED PHOTOTHERMAL-CHEMOTHERAPY

4.1 Introduction

4.2 Materials and Methods

4.2.1 Synthesis of block copolymer

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